ABSTRACT
Objective To investigate the relationship between interleukin (IL)-17 and IL-10 in psoriasis.Methods The expression of IL-17 and IL-10 was measured by enzyme-linked immunosorbent assay in 32 patients with psoriasis (psoriasis group) and 30 normal controls (control group).The correlation of IL-17 and IL-10 was analyzed.Results The expression of IL-17 in psoriasis group was higher than that in control group[(57.59 ± 11.99) ng/L vs.(33.27 ± 6.49) ng/L] (t =9.84,P ＜ 0.01).The expression of IL-10 in psoriasis group was lower than that in control group [(25.38 ± 4.32) ng/L vs.(32.01 ± 5.54) ng/L] (t =5.27,P＜ 0.01).There was negative correlation between IL-17 and IL-10 in patients with psoriasis (r =-0.70,P ＜ 0.01).Conclusion The pathogenesis of psoriasis may be related to imbalance of IL-17 and IL-10.
ABSTRACT
We report a case of cutaneous and subcutaneous phaeohyphomycosis caused by Exophiala jeanselmei after renal transplantation in Guangdong. A 66-year-old man who had a renal transplantation 6 years ago was admitted in October 2011 for the presence of 16 nodules (0.5-1.5 cm) found on his right middle finger, wrist and forearm for 5 months. Microscopic examination of the purulent exudate showed segmented and branched brown mycelium, and tissue biopsy and PAS staining showed fungal hyphae. The isolate was processed for morphological identification and molecular sequence analysis. A black colony was found after culture of the isolate on SDA at 26 degrees Celsius;, and small culture identified the isolate as Exophiala jeanselmei. ITS sequence analysis of the isolate showed a 100% homology with Exophiala jeanselmei. E-test strip was used in drug sensitivity test, and the isolate was sensitive to amphotericin B, voriconazole, itraconazole and fluconazole, but resistant to 5-flucytosine and caspofungin. Good response was obtained with surgical intervention, local injection and systemic antifungal treatment.